重组人CD38 蛋白（Recombinant Human CD38 Protein），GMP级

产品货号：GMP-TL687

产品描述（Description）

CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP- ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.

分子别名（Synonym）

 ADPRC 1、 ADPRC1、 T10、cADPr hydrolase 1

表达宿主（Expression host）

HEK293 细胞

来源（Source）

Human

蛋白序列（Protein Sequence）

DNA序列编码人CD38（UniProtKB/Swiss-Prot:Q01973）表达带有Fc标签在C末端

分子量（Molecular Weight）

重组人 CD38 蛋白 包含 489 个氨基酸，预测理论分子量为 56.8kD

纯度（Purity）

≥95%采用 SDS-PAGE 凝胶和高效液相色谱分析

内毒素（Endotoxin）

＜0.1EU/ug

生物活性（Biological Activity）

固定人 CD38(Fc Tag) at 1 ug/mL (100 uL/well) 能够结合人源化抗 CD38 抗体的线性范围是 1-5ng/mL

使用说明（Instructions）

稳定性和储存：冻干的样本的可以在4℃保存24个月，溶解后的液体可以于-20℃保存6-12个月，并且避免反复冻融

组成（Component）

含有6%甘露醇的无菌PBS（PH 7.4）的冻干粉

参考文献

1、Pepys CD38 Controls the Innate Immune Response against Listeria monocytogenes. Timo Lischke, Kira Heesch, Valéa Schumacher, Michael Schneider, Friedrich Haag, Friedrich Koch-Nolte, Hans-Willi Mittrücker Infect Immun. 2013 Nov; 81(11): 4091–4099. doi: 10.1128/IAI.00340-13 

2、Characterization of CD38 in the major cell types of the heart: endothelial cells highly express CD38 with activation by hypoxia-reoxygenation triggering NAD(P)H depletion. James Boslett, Craig Hemann, Fedias L. Christofi, Jay L. Zweier Am J Physiol Cell Physiol. 2018 Mar 1; 314(3): C297–C309. Published online 2017 Nov 29. doi: 10.1152/ajpcell.00139.2017

   注意：For research and manufacturing use.