首页 > 产品中心 > 靶点蛋白 > 重组人CD38蛋白

Product

产品中心
人源化抗体 细胞因子 免疫磁珠 DNA/RNAi试剂 靶点蛋白 培养基

重组人CD38蛋白

CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family.

100μg/¥5400
咨询电话 400-010-5556

产品货号:GMP-TL687

重组人CD38 蛋白(Recombinant Human CD38 Protein),GMP级

 

产品货号:GMP-TL687


 

产品描述(Description)

 

CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP- ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.

 

 

 

分子别名(Synonym)

 

 ADPRC 1、 ADPRC1、 T10、cADPr hydrolase 1

 

 

 

表达宿主(Expression host)

 

HEK293 细胞

 

 

 

来源(Source)

 

Human

 

 

 

蛋白序列(Protein Sequence)

 

DNA序列编码人CD38(UniProtKB/Swiss-Prot:Q01973)表达带有Fc标签在C末端

 

 

 

分子量(Molecular Weight)

 

重组人 CD38 蛋白 包含 489 个氨基酸,预测理论分子量为 56.8kD

 

 

 

纯度(Purity)

 

≥95%采用 SDS-PAGE 凝胶和高效液相色谱分析

 

 

 

内毒素(Endotoxin)

 

<0.1EU/ug

 

 

 

生物活性(Biological Activity)

 

固定人 CD38(Fc Tag) at 1 ug/mL (100 uL/well) 能够结合人源化抗 CD38 抗体的线性范围是 1-5ng/mL

 

 

 

使用说明(Instructions)

 

稳定性和储存:冻干的样本的可以在4℃保存24个月,溶解后的液体可以于-20℃保存6-12个月,并且避免反复冻融

 

 

 

组成(Component)

 

含有6%甘露醇的无菌PBS(PH 7.4)的冻干粉

 

 


参考文献


1、Pepys CD38 Controls the Innate Immune Response against Listeria monocytogenes. Timo Lischke, Kira Heesch, Valéa Schumacher, Michael Schneider, Friedrich Haag, Friedrich Koch-Nolte, Hans-Willi Mittrücker Infect Immun. 2013 Nov; 81(11): 4091–4099. doi: 10.1128/IAI.00340-13 

2、Characterization of CD38 in the major cell types of the heart: endothelial cells highly express CD38 with activation by hypoxia-reoxygenation triggering NAD(P)H depletion. James Boslett, Craig Hemann, Fedias L. Christofi, Jay L. Zweier Am J Physiol Cell Physiol. 2018 Mar 1; 314(3): C297–C309. Published online 2017 Nov 29. doi: 10.1152/ajpcell.00139.2017




   注意:For research and manufacturing use.

质检报告(COA)下载

(下载报告需要同时满足两个条件,同时输入“产品货号”和“生产批号”,满足即可搜索出产品质检报告)

如何在产品瓶上找到产品批号?

相关产品推荐:

重组人OX40 Ligand蛋白

北京同立海源生物

货号:GMP-TL726 规格:≥95%
了解详情

重组人4-1BB蛋白

北京同立海源生物

货号:GMP-TL694 规格:≥95%
了解详情

重组人CD19蛋白

北京同立海源生物

货号:GMP-TL665 规格:≥95%
了解详情

扫码关注微信公众号

北京同立海源生物科技有限公司

电话:400-010-5556

网址:www.seafrom.com

Q Q:2850881917 微信客服:18610367518

地址:北京市大兴区中关村科技园区大兴生物医药产业基地华佗路50号院13号楼

北京同立海源生物科技有限公司版权所有   ICP备案号:京ICP备13036197号   电话:400-010-5556           微信客服:18610367518      QQ客服:2850881917