重组人CRP蛋白（Recombinant Human CRP Protein），GMP级

产品货号：GMP-TL736

产品描述（Description）

t are noncovalently linked to form the pentameter. Human CRP shares 71% and 64% amino acid sequence homology with mouse and rat respectively. CRP, synthesized by hepatocytes, is a major acute phase serum protein in human. IL6, IL1 and

glucocorticoids are the major inducer of the CRP gene. The physiological role of CRP is to bind to phosphocholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system. C

RP binds to phosphocholine on microbes and damaged cells and enhances phagocytosis by macrophages. Thus, CRP parti cipates in the clearance of necrotic and apoptotic cells. CRP rises up to 50,000-fold in acute inflammation, such as

infection. It rises above normal limits within 6 hours, and peaks at 48 hours. It shalf-life is constant, and therefo re its level is mainly determined by the rate of production. It has been shown that high levels of CRP in human sisassoc iated with an increased risk of cardiovascular diseases.

分子别名（Synonym）

CRP,C-reactive Protein

表达宿主（Expression host）

HEK293 细胞

蛋白序列（Protein Sequence）

DNA序列编码人CRP（ NCBI Reference Sequence: NP_000558.2）表达达带有His 标签在C 末端

分子量（Molecular Weight）

重组人CRP蛋白 包含 207 个氨基酸，预测理论分子量为 24.7 kD

纯度（Purity）

≥95%采用 SDS-PAGE 凝胶和高效液相色谱分析

内毒素（Endotoxin）

＜0.1EU/ug

提纯方法（ Purification Method ）

层析纯化

使用说明（Instructions）

稳定性和储存：冻干的样本的可以在4℃保存24个月，溶解后的液体可以于-20℃保存6-12个月，并且避免反复冻融

组成（Component）

含有6%甘露醇的无菌PBS（PH 7.4）的冻干粉

 注意：For research and manufacturing use.